Drug Effect Of Fucoidan Sulfate
May 19, 2018
1. immune regulation
Fucoidan can induce interleukin-1 (IL-1) and interferon-gamma (IFN-γ) production in vitro; in vivo administration can enhance T cells, B cells, macrophages (Mφ) and natural killing The function of the cell (NK) promotes the primary antibody response of sheep red blood cells (SRBC). In addition, Laminarin is a mouse B-lymphocyte mitogen that also activates rat spleen lymphocytes and human peripheral blood mononuclear cells. Thus, it was proved that Laminaria japonica polysaccharide has the function of enhancing immune function.
2. anticoagulant effect
Fucoidan sulfate has obvious anticoagulant and profibrinolytic pharmacological activities, and its activity is enhanced with the increase of fucoidan sulfate concentration, but the anticoagulant effect is due to the fact that the polysaccharide has a relatively large molecular weight and is not easily absorbed. Less than heparin, only applicable to patients with high blood viscosity, can only be used as a drug or health product to prevent thrombosis. The study found that the anticoagulant effect of polysaccharides is also related to the mode of ingestion, and the effect of intravenous injection is significantly higher than that of intraperitoneal injection.
3. hypoglycemic effect
Shandong University's research results show that fucoidan sulfate has a significant hypoglycemic effect and can maintain its hypoglycemic effect within 24 hours. Fucoidan sulfate may protect it when islet cells are damaged. After injecting a certain amount of fucoidan sulfate into alloxan-induced diabetic mice, symptoms of diabetes, water intake, and glucose tolerance were significantly improved.
4. other effects
Fucoidan sulfate has good effects on the treatment of cardiovascular and cerebrovascular diseases and chronic renal failure in the early and intermediate stages. It has no toxic or side effects, and it is particularly effective in improving renal function and improving renal clearance for creatinine. According to the study of Zhai Meiyu, GS201 fucoidan extracted from kelp has obvious nutritional effects on hippocampal neurons and cortical nerve cells, and can increase the survival rate of neurons, and shows a certain dose-effect relationship.