Anti-inflammatory Effects Of Fucoxanthin
Apr 14, 2018
Fucoxanthin has an inhibitory effect on the exudation of inflammatory mediators induced by endotoxin in a dose-dependent manner. Its anti-inflammatory effect is comparable to that of prednisolone, indicating that fucoxanthin has an inflammatory infiltration in mice induced by endotoxin. , NO, PGE2 and tumor necrosis factor have a certain inhibitory effect. Its anti-inflammatory effect is mainly through inhibiting the exudation of NO induced by lipopolysaccharide-induced macrophages. RT-PCR analysis showed that the mRNA of NO synthase and cyclooxygenase was inhibited by fucoxanthin, and Tumor necrosis factor, interleukin IL-1β and IL-6, and mRNA cell survivin expression were both inhibited by fucoxanthin in a dose-dependent manner. These results indicate that fucoxanthin may have multiple inflammatory responses. Has an important role.