(1) Skin cancer
Fucoxanthin can inhibit the increase of ornithine decarboxylase activity in mouse epidermis induced by the strong skin cancer promoter tetradecanoylphorbol-13-acetate (TPA), while it can inhibit TPA-induced human herpes Virus activation, thereby inhibiting TPA-induced skin tumors.
(2) Colon cancer
Fucoxanthin has an inhibitory effect on the formation of duodenal cancer induced by N-ethyl-N'-nitro-N-nitrosoguanidine. Fucoxanthin can significantly inhibit the growth of colon cancer cell lines, including Caco-2, HT-29 and DLD-1. It induces DNA fragmentation in colon cancer cells, promotes apoptosis, and inhibits the expression of apoptosis-related protein Bcl-2.
Fucoxanthin can inhibit the proliferation of human colon cancer cell line WiDr cells in a dose-dependent manner, and can block the cell cycle at G0/G1 phase and induce apoptosis.
(3) Hematologic Tumors
Effect of fucoxanthin on acute myeloid leukemia HL-60 cell line. Fucoxanthin exerts a significant inhibitory effect on proliferation of HL-60 cells. Effect of fucoxanthin on adult T-lymphocytic leukemia. Fucoxanthin and its metabolite fucoxanthin can inhibit the survival of human T-cell lymphotropic virus type 1 (HTLV-1) infected T cells and adult T cell leukemia cells.
(4) Prostate cancer
Fucoxanthin can significantly reduce the survival rate of prostate cancer cells and induce apoptosis. Fucoxanthin and its metabolite fucoxanthin inhibit PC-3 cell proliferation and activate Caspase-3 to induce apoptosis.
(5) Liver Cancer
Fucoxanthin has an inhibitory effect on the growth of human hepatoma HepG2 cells and can arrest cells in G0/G1 phase and inhibit the phosphorylation of Ser780 site of Rb protein.